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An Outline of Parkinson’s Disease

August 4, 2010

I. What Do We Know?

II. Systems Involved in PD

A. Immune System
B. Endocrine System
C. Gastroenteric System
D. Central Nervous System
E. “Secondary” Systems

III. Elements of Progression of PD

A. Predisposing Factors
B. Initiating Triggers
C. Ongoing Processes

1. Oxidation
2. Excitotoicity
3. Mitochondrial Failure
4. Inflammation and Microglia
5. Stress and the HPA
6. Autoimmunity

IV. Interactive Systems and Neuroactive Messengers

A. Neurotransmitters, Hormones, and Cytokines

V. Time Periods Related to PD

A. Preconception
B. Prenatal
C. Prepuberty
D. Puberty
E. Young Adult
F. Mid-Life
G. Senior

VI. Environmental Factors and PD

A. Lipopolysaccharide (LPS)
B. Pathogens
C. Ultrafine Particulates
D. Toxins
E. Epigenetics

VII. Internal Factors and PD

A. Alpha-Synuclein
B. Blood Brain Barrier
C. Circadian Rhythms
D. Constipation
E. Electrolytes and Ion Channels
F. Genetics
G. Metabolic Factors and Nutrition

VIII. Treatment, Repair, and Cure

A. Therapeutics
B. Neurogenesis
C. Symptoms

IX. Miscellany

A. Historical View of PD
B. Homeostasis
C. Related Disorders
D. Rhythmic Disruption

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